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Stay connected with the Goeddel Family Technology Sandbox by checking this page for the latest webinars, workshops, demos, and announcements, or subscribe to the Technology Sandbox Newsletter.
For additional at the School of Biological Sciences, check out the BioSci Seminars and Events Calendar.
Department of Structural Biology, St. Jude Children’s Research Hospital
When: May 6 | 11:00 AM – 12:00 PM
Where: Kavli Auditorium, 3rd Floor Tata Hall, UC San Diego
Abstract: Understanding the architecture of protein complexes in their native environment is essential for understanding their biological function. However, many transient and low-affinity interactions are missed by protein-protein interaction mapping methods. We are pioneering novel crosslinking mass spectrometry methods to map weak and transient protein-protein interactions directly in cells, which can lead directly to structure solution by Cryo-EM. Using these approaches, we uncover novel complexes in Salmonella Typhimurium, including previously uncharacterized RNA polymerase interactors. In parallel, we develop a targeted enrichment strategy called PhIX-MS to define the interactomes of human protein assemblies. Applying this approach to the proteasome, we identify and validate the binding sites of TXNL1, UBE3C, and the assembly chaperone PSMD5/S5b. Our methods provide a broadly applicable strategy for dissecting protein complex architecture in native cellular contexts.
This seminar is hosted in partnership with the Goeddel Family Technology Sandbox. Professor Lisa Jones is the faculty host.


The 3rd UC San Diego School of Biological Sciences Bridging Biomedical Breakthroughs Summit showcases high-potential faculty innovations with strong translational and commercial potential, convening key investors, entrepreneurs, and industry leaders to explore strategic partnership and venture opportunities. Join us to help shape the dialogue, identify early-stage opportunities, and catalyze collaborations that translate breakthrough science into meaningful impact.
Date: Friday, June 5, 2026 at 1:00-5:30PM
Registration: Now open
Questions: Contact Melissa Hoon, Director, Corporate Relations and Professional Development, School of Biological Sciences.